Cecum Ligation And Puncture (clp)-induced Sepsis Model

Sepsis is a serious medical condition characterized by dysregulated systemic inflammatory responses followed by immunosuppression, which remains a major challenge for scientists and clinicians. Thus, deep investigation into the pathogenic mechanism of this disease is urgently required to promote the development of novel and more effective therapeutic agents. To study the pathophysiology of sepsis, diverse animal models have been developed, among which, polymicrobial sepsis induced by cecal ligation and puncture (CLP) is the most widely used model because it closely resembles the progression and characteristics of human sepsis. Specifically, CLP-induced rodent sepsis model display disease patterns with typical signs of sepsis or septic shock, such as hypothermia, tachycardia, and tachypnea. It is generally accepted that CLP reflects clinical reality more accurately than previous techniques, such as injection of endotoxin or even purified bacteria into rodents. https://www.creative-biolabs.com/drug-discovery/therapeutics/cecum-ligation-and-puncture-clp-induced-sepsis-model.htm